BDBM278945 4-{8-amino-3- [(7R,9aS)-7-methyl-2- (1-methylethyl)-4- oxooctahydro-2H- pyrido[1,2-a]pyrazin- 7-yl]imidazo[1,5-a] pyrazin-1-yl}-3- ethoxy-N-[1-methyl- 5-(trifluoromethyl)- 1H-pyrazol-3- yl]benzamide::US10040805, Example 15

SMILES CCOc1cc(ccc1-c1nc(n2ccnc(N)c12)[C@]1(C)CC[C@H]2CN(CC(=O)N2C1)C(C)C)C(=O)Nc1cc(n(C)n1)C(F)(F)F

InChI Key InChIKey=NWIWNHWXFQJQED-PKHCJMHPSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278945   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278945(4-{8-amino-3- [(7R,9aS)-7-methyl-2- (1-methylethyl...)
Affinity DataIC50:  1.27nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent