BDBM278947 4-{8-amino-3- [(6R,8aS)-6-methyl-3- oxooctahydroindolizin- 6-yl]imidazo[1,5-a] pyrazin-1-yl}-N-[4- (trifluoromethyl) pyridin-2-yl] benzamide::US10040805, Example 17

SMILES C[C@]1(CC[C@H]2COC(=O)N2C1)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12

InChI Key InChIKey=CODVPNZMAMDXSE-HFJWLAOPSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278947   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278947(4-{8-amino-3- [(6R,8aS)-6-methyl-3- oxooctahydroin...)
Affinity DataIC50:  0.180nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent