BDBM279657 US10035797, Compound 1::US10428068, Compound 1::US10844056, Compound 1::US11560377, Compound 22::US9630965, Compound 1

SMILES Nc1nccc2n(CCCC#C)c(Sc3cc4OCOc4cc3Br)nc12

InChI Key InChIKey=NMAKGVDSCRRAOU-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 279657   

TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Curis

US Patent
LigandPNGBDBM279657(US10035797, Compound 1 | US10428068, Compound 1 | ...)
Affinity DataIC50:  550nMT: 2°CAssay Description:The Hsp90 chaperone assay was performed to measure the ability of HSP90 protein to refold the heat-denatured luciferase protein. HSP90 was first incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Curis

US Patent
LigandPNGBDBM279657(US10035797, Compound 1 | US10428068, Compound 1 | ...)
Affinity DataIC50:  550nMpH: 7.3Assay Description:A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHsp90 co-chaperone Cdc37(Homo sapiens (Human))
Curis

US Patent
LigandPNGBDBM279657(US10035797, Compound 1 | US10428068, Compound 1 | ...)
Affinity DataIC50:  550nMAssay Description:The Hsp90 chaperone assay was performed to measure the ability of HSP90 protein to refold the heat-denatured luciferase protein. HSP90 was first incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Curis

US Patent
LigandPNGBDBM279657(US10035797, Compound 1 | US10428068, Compound 1 | ...)
Affinity DataIC50:  550nMAssay Description:A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHsp90 co-chaperone Cdc37(Homo sapiens (Human))
Curis

US Patent
LigandPNGBDBM279657(US10035797, Compound 1 | US10428068, Compound 1 | ...)
Affinity DataIC50:  550nMAssay Description:The Hsp90 chaperone assay was performed to measure the ability of HSP90 protein to refold the heat-denatured luciferase protein. HSP90 was first incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Curis

US Patent
LigandPNGBDBM279657(US10035797, Compound 1 | US10428068, Compound 1 | ...)
Affinity DataIC50:  5.50E+3nMAssay Description:A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Curis

US Patent
LigandPNGBDBM279657(US10035797, Compound 1 | US10428068, Compound 1 | ...)
Affinity DataIC50:  550nMAssay Description:The Hsp90 chaperone assay was performed to measure the ability of HSP90 protein to refold the heat-denatured luciferase protein. HSP90 was first incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Curis

US Patent
LigandPNGBDBM279657(US10035797, Compound 1 | US10428068, Compound 1 | ...)
Affinity DataIC50:  550nMAssay Description:A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHsp90 co-chaperone Cdc37(Homo sapiens (Human))
Curis

US Patent
LigandPNGBDBM279657(US10035797, Compound 1 | US10428068, Compound 1 | ...)
Affinity DataIC50:  550nMAssay Description:The Hsp90 chaperone assay was performed to measure the ability of HSP90 protein to refold the heat-denatured luciferase protein. HSP90 was first incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Curis

US Patent
LigandPNGBDBM279657(US10035797, Compound 1 | US10428068, Compound 1 | ...)
Affinity DataIC50:  550nMAssay Description:A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Curis

US Patent
LigandPNGBDBM279657(US10035797, Compound 1 | US10428068, Compound 1 | ...)
Affinity DataIC50:  550nMAssay Description:HSP90: A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent