BDBM279728 5-Chloro-3,3-dimethyl-2-[5-[2-(1-methylpyrazole-4-carbonyl)-2,6-diazaspiro[3.3]-heptan-6-yl]-3-pyridyl]isoindolin-1-one::US10035804, Example 1

SMILES Cn1cc(cn1)C(=O)N1CC2(C1)CN(C2)c1cncc(c1)N1C(=O)c2ccc(Cl)cc2C1(C)C

InChI Key InChIKey=XPPRAIYPPOVBQQ-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 279728   

TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM279728(5-Chloro-3,3-dimethyl-2-[5-[2-(1-methylpyrazole-4-...)
Affinity DataEC50:  0.00200nMAssay Description:Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM279728(5-Chloro-3,3-dimethyl-2-[5-[2-(1-methylpyrazole-4-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human CYP11B2 expressed in human renal leiomyoblastoma cells harboring FDXR/FDX using 1-deoxycorticosterone as substrate by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM279728(5-Chloro-3,3-dimethyl-2-[5-[2-(1-methylpyrazole-4-...)
Affinity DataEC50:  11.3nMAssay Description:Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent