BDBM280356 4-[[2-amino-6-(5-chloro-2-fluoro-phenyl)-3-isopropenyl-4-pyridyl]amino]-N-[(2S)-2-hydroxypropyl]pyridine-3-carboxamide::US10030004, Compound 23a::US11053216, Compound 23a::US11702401, Compound 23a

SMILES COC(=O)c1cnccc1Nc1cc(nc(NC(=O)OC(C)(C)C)c1C(C)=C)-c1cc(Cl)ccc1F

InChI Key InChIKey=UXFTVPGMWIESDP-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 280356   

TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280356(4-[[2-amino-6-(5-chloro-2-fluoro-phenyl)-3-isoprop...)
Affinity DataIC50:  5.67E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280356(4-[[2-amino-6-(5-chloro-2-fluoro-phenyl)-3-isoprop...)
Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280356(4-[[2-amino-6-(5-chloro-2-fluoro-phenyl)-3-isoprop...)
Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280356(4-[[2-amino-6-(5-chloro-2-fluoro-phenyl)-3-isoprop...)
Affinity DataIC50:  33.1nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280356(4-[[2-amino-6-(5-chloro-2-fluoro-phenyl)-3-isoprop...)
Affinity DataIC50:  16.9nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1B(Mus musculus (Mouse))
Medivation Technologies

US Patent
LigandPNGBDBM280356(4-[[2-amino-6-(5-chloro-2-fluoro-phenyl)-3-isoprop...)
Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280356(4-[[2-amino-6-(5-chloro-2-fluoro-phenyl)-3-isoprop...)
Affinity DataIC50:  5.67E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280356(4-[[2-amino-6-(5-chloro-2-fluoro-phenyl)-3-isoprop...)
Affinity DataIC50: >1.00E+5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280356(4-[[2-amino-6-(5-chloro-2-fluoro-phenyl)-3-isoprop...)
Affinity DataIC50: >1.00E+5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280356(4-[[2-amino-6-(5-chloro-2-fluoro-phenyl)-3-isoprop...)
Affinity DataIC50:  33.1nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280356(4-[[2-amino-6-(5-chloro-2-fluoro-phenyl)-3-isoprop...)
Affinity DataIC50:  16.9nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBone morphogenetic protein 10(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280356(4-[[2-amino-6-(5-chloro-2-fluoro-phenyl)-3-isoprop...)
Affinity DataIC50: >1.00E+5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280356(4-[[2-amino-6-(5-chloro-2-fluoro-phenyl)-3-isoprop...)
Affinity DataIC50:  5.67E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280356(4-[[2-amino-6-(5-chloro-2-fluoro-phenyl)-3-isoprop...)
Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280356(4-[[2-amino-6-(5-chloro-2-fluoro-phenyl)-3-isoprop...)
Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280356(4-[[2-amino-6-(5-chloro-2-fluoro-phenyl)-3-isoprop...)
Affinity DataIC50:  33.1nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280356(4-[[2-amino-6-(5-chloro-2-fluoro-phenyl)-3-isoprop...)
Affinity DataIC50:  16.9nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280356(4-[[2-amino-6-(5-chloro-2-fluoro-phenyl)-3-isoprop...)
Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent