BDBM283443 US10023557, Example 95::US10266515, Example 95::US10308637, Example 95::US11021463, Example 95::US9611252, Example 95::methyl 6-((4-(((6-amino-2-methylpyridin-3- yl)methyl)carbamoyl)pyridin-2-yl)methyl)-3- chloroquinoline-8-carboxylate
SMILES COC(=O)c1cc(Cc2cc(ccn2)C(=O)NCc2ccc(N)nc2C)cc2cc(Cl)cnc12
InChI Key InChIKey=JHWMKRJZPWMJLH-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 283443
Affinity DataIC50: <100nMpH: 7.5Assay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Lifesci Pharmaceuticals
US Patent
Lifesci Pharmaceuticals
US Patent
Affinity DataIC50: <100nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair