BDBM283456 N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((5-methyl-1H-indazol-1- yl)methyl)isonicotinamide::US10023557, Example 108::US10266515, Example 108::US10308637, Example 108::US11021463, Example 108::US9611252, Example 108
SMILES Cc1ccc2n(Cc3cc(ccn3)C(=O)NCc3c(C)cc(N)nc3C)ncc2c1
InChI Key InChIKey=PJQHDAQZXYWCRS-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 283456
Affinity DataIC50: <100nMpH: 7.5Assay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Lifesci Pharmaceuticals
US Patent
Lifesci Pharmaceuticals
US Patent
Affinity DataIC50: <100nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair