BDBM287003 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro-3,5-dimethoxyphenyl)-2-((2,2-difluoroethyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one::US10294223, Cpd No. 35::US11078199, Cpd 35::US9567334, Example 35::US9815834, Compound 35

SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(NCC(F)F)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O

InChI Key InChIKey=KVNSXBAQSWMTDX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 287003   

TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

US Patent
LigandPNGBDBM287003(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)
Affinity DataIC50:  3.80nMT: 2°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

US Patent
LigandPNGBDBM287003(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)
Affinity DataIC50:  3.80nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

US Patent
LigandPNGBDBM287003(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)
Affinity DataIC50:  4nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Principia Biopharma

US Patent
LigandPNGBDBM287003(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)
Affinity DataIC50:  4nMAssay Description:The cell-based effects of FGFR inhibitors were determined by measuring inhibition of FGFR-dependent cell line growth. The cell lines SNU-16 was used ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent