BDBM287526 (R)-8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)ethyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-((1-methoxypropan-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one::US10294223, Cpd No. 116::US11078199, Cpd 116::US9567334, Example 116::US9815834, Compound 116

SMILES COC[C@@H](C)Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN(C)C3CN(C3)C(=O)C=C)c2n1

InChI Key InChIKey=URIOWDLDOGYPLK-MRXNPFEDSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 287526   

TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

US Patent
LigandPNGBDBM287526((R)-8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)e...)
Affinity DataIC50:  1.70nMT: 2°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

US Patent
LigandPNGBDBM287526((R)-8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)e...)
Affinity DataIC50:  1.70nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

US Patent
LigandPNGBDBM287526((R)-8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)e...)
Affinity DataIC50:  1.70nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

US Patent
LigandPNGBDBM287526((R)-8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)e...)
Affinity DataIC50:  1nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Principia Biopharma

US Patent
LigandPNGBDBM287526((R)-8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)e...)
Affinity DataIC50:  1nMAssay Description:The cell-based effects of FGFR inhibitors were determined by measuring inhibition of FGFR-dependent cell line growth. The cell lines SNU-16 was used ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent