BDBM28762 (2R)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]ethyl}phenoxy)-2-methylbutanoic acid::LT160 (ureidofibrate derivative), (R)-1

SMILES CCCCCCCN(CCc1ccc(O[C@](C)(CC)C(O)=O)cc1)c1nc2ccccc2o1

InChI Key InChIKey=QPKIEBNVIOELIR-HHHXNRCGSA-N

Data  2 KI  2 Kd  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 28762   

TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Istituto Tumori"Giovanni Paolo II"

Curated by ChEMBL
LigandPNGBDBM28762((2R)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)
Affinity DataKi:  88nMAssay Description:Displacement of [3H]rosiglitazone from N-terminal His-tagged human PPARgamma ligand binding domain expressed in Escherichia coli BL21 DE3 cells by sc...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Istituto Tumori"Giovanni Paolo II"

Curated by ChEMBL
LigandPNGBDBM28762((2R)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)
Affinity DataKi:  88nM ΔG°:  -9.52kcal/molepH: 7.5 T: 2°CAssay Description:The scintillation proximity assay was performed in 96-well plates containing polylysine-coated yttrium silicate beads, His-PPARgamma-LBD, and [3H]ros...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Istituto Tumori"Giovanni Paolo II"

Curated by ChEMBL
LigandPNGBDBM28762((2R)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at human GAL4-fused PPARalpha ligand binding domain expressed in HepG2 cells after 20 hrs by luciferase reporter gene transactivatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Istituto Tumori"Giovanni Paolo II"

Curated by ChEMBL
LigandPNGBDBM28762((2R)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)
Affinity DataKd:  270nMAssay Description:Binding affinity to PPARgamma ligand binding domain by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Istituto Tumori"Giovanni Paolo II"

Curated by ChEMBL
LigandPNGBDBM28762((2R)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)
Affinity DataKd:  685nM EC50:  73.3nMpH: 7.5 T: 2°CAssay Description:Kd values were obtained by incubating His-PPARgamma-LBD with biotinylated peptide, europium-labeled anti-histidine antibody, and allophycocyanin-labe...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Istituto Tumori"Giovanni Paolo II"

Curated by ChEMBL
LigandPNGBDBM28762((2R)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)
Affinity DataEC50:  70nMAssay Description:Agonist activity at human GAL4-fused PPARgamma ligand binding domain expressed in HepG2 cells after 20 hrs by luciferase reporter gene transactivatio...More data for this Ligand-Target Pair