BDBM288468 4-(8-amino-1-(2- methoxy-4-((4- (trifluoromethyl) pyridin-2- yl)carbamoyl)phenyl) imidazo[1,5-a]pyrazin- 3-yl)cubane-1- carboxylic acid::US10087188, Example 75

SMILES COc1cc(ccc1-c1nc(n2ccnc(N)c12)C12C3C4C1C1C2C3C41C(O)=O)C(=O)Nc1cc(ccn1)C(F)(F)F

InChI Key InChIKey=KPXJLJDFXWFGCN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288468   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM288468(4-(8-amino-1-(2- methoxy-4-((4- (trifluoromethyl) ...)
Affinity DataIC50:  0.560nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent