BDBM288514 (1S,3R)-3-(8-amino-1- {4-[(4- cyclopropylpyridin-2- yl)carbamoyl]-2- ethoxy-6- fluorophenyl}imidazo [1,5-a]pyrazin-3-yl)- 1,2,2- trimethylcyclopentane carboxylic acid::US10087188, Example 121

SMILES CCOc1cc(cc(F)c1-c1nc([C@@H]2CC[C@](C)(C(O)=O)C2(C)C)n2ccnc(N)c12)C(=O)Nc1cc(ccn1)C1CC1

InChI Key InChIKey=XHDSBAPGNZUDIX-MQFAKOPTSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288514   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM288514((1S,3R)-3-(8-amino-1- {4-[(4- cyclopropylpyridin-2...)
Affinity DataIC50:  0.370nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent