BDBM288589 US10087188, Example 200::trans-4-{(2R,5S)-2-[8-amino- 5-chloro-1-(2-fluoro-4-{[4- (trifluoromethyl)pyridin-2- yl]carbamoyl}phenyl)imidazo [1,5-a]pyrazin-3-yl]-5- methylmorpholin-4-yl}-1- methylcyclohexanecarboxylic acid

SMILES C[C@H]1CO[C@H](CN1[C@H]1CC[C@@](C)(CC1)C(O)=O)c1nc(-c2ccc(cc2F)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)ncc(Cl)n12

InChI Key InChIKey=WADWUCNISBWNJV-MTMABVINSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288589   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM288589(US10087188, Example 200 | trans-4-{(2R,5S)-2-[8-am...)
Affinity DataIC50:  0.420nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent