BDBM290375 (3R,4S)-3-amino-4-(3-boronopropyl)-1-isobutylpyrrolidine-3- carboxylic acid::US10098902, Example 11::US10603330, Example 11::US11389464, Example 11

SMILES CC(C)CN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O

InChI Key InChIKey=ZLYYDBMCIDDQAZ-JQWIXIFHSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 290375   

TargetArginase-1(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM290375((3R,4S)-3-amino-4-(3-boronopropyl)-1-isobutylpyrro...)
Affinity DataIC50:  625nMpH: 7.4 T: 2°CAssay Description:Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM290375((3R,4S)-3-amino-4-(3-boronopropyl)-1-isobutylpyrro...)
Affinity DataIC50:  1.50E+3nMpH: 7.4 T: 2°CAssay Description:Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetArginase-1(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM290375((3R,4S)-3-amino-4-(3-boronopropyl)-1-isobutylpyrro...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM290375((3R,4S)-3-amino-4-(3-boronopropyl)-1-isobutylpyrro...)
Affinity DataIC50:  1.50E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetArginase-1(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM290375((3R,4S)-3-amino-4-(3-boronopropyl)-1-isobutylpyrro...)
Affinity DataIC50:  390nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM290375((3R,4S)-3-amino-4-(3-boronopropyl)-1-isobutylpyrro...)
Affinity DataIC50:  625nMAssay Description:Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM290375((3R,4S)-3-amino-4-(3-boronopropyl)-1-isobutylpyrro...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent