BDBM292797 US10105367, Example 82::US10376514, Example 82

SMILES Clc1ccc(Cn2c3sc4CCCCc4c3c3ncnn3c2=O)cc1

InChI Key InChIKey=SRUIZVZXCPBTGE-UHFFFAOYSA-N

Data  14 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 292797   

TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart Neuroscience (Cayman)

US Patent
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50:  550nMT: 2°CAssay Description:PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE3A (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart Neuroscience (Cayman)

US Patent
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50:  460nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50:  370nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE5A1 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in F...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of PDE4D3 (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of PDE2A1 (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart Neuroscience (Cayman)

US Patent
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50:  550nMAssay Description:The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...More data for this Ligand-Target Pair
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE8A1 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in F...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE9A2 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in F...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50:  460nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human PDE7A1 (122-end residues) expressed in Baculovirus infected Sf9 insect cells assessed as decrea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE11A4 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50:  3.50E+3nMAssay Description:Binding affinity to human Sphingosine 1-phosphate receptor 1 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed