BDBM293423 US10106527, Compound 461::US10106527, Compound 9::US10544128, Compound 9::US11548872, Compound 461::US20230286945, Compound 461::US9951048, Compound 461

SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CCNCC3)cc2c1

InChI Key InChIKey=UJSHIQRDLZVYOW-UHFFFAOYSA-N

Data  20 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 293423   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Samumed

US Patent
LigandPNGBDBM293423(US10106527, Compound 461 | US10106527, Compound 9 ...)
Affinity DataEC50:  0.400nMT: 2°CAssay Description:Briefly, recombinant DYRK1A kinase, ATP and Ser/Thr peptide 18 were prepared in 1× Kinase buffer to final concentrations of 0.19 μg/mL, 30 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Samumed

US Patent
LigandPNGBDBM293423(US10106527, Compound 461 | US10106527, Compound 9 ...)
Affinity DataEC50:  3.40E+3nMT: 2°CAssay Description:Briefly, recombinant GSK3β kinase, ATP and Ser/Thr peptide 09 are prepared in 1× Kinase buffer to final concentrations of 0.04 μg/mL, 46 &#...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Samumed

US Patent
LigandPNGBDBM293423(US10106527, Compound 461 | US10106527, Compound 9 ...)
Affinity DataEC50:  3.20E+3nMT: 2°CAssay Description:Briefly, recombinant GSK3β kinase, ATP and Ser/Thr peptide 09 are prepared in 1× Kinase buffer to final concentrations of 0.04 μg/mL, 46 &#...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Samumed

US Patent
LigandPNGBDBM293423(US10106527, Compound 461 | US10106527, Compound 9 ...)
Affinity DataEC50:  1.5nMT: 2°CAssay Description:Briefly, recombinant DYRK1A kinase, ATP and Ser/Thr peptide 18 were prepared in 1× Kinase buffer to final concentrations of 0.19 μg/mL, 30 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent