BDBM294486 1-{1-Cyclopropyl-2-[2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-ethyl]-1H-imidazol-4-yl}-pyrrolidin-2-one::Roche-Dataset for PDE10A, Compound 200::US9586970, 7

SMILES Cc1cnc(C)c2nc(CCc3nc(cn3C3CC3)N3CCCC3=O)nn12

InChI Key InChIKey=XUHQREABUOAZHL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 294486   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM294486(1-{1-Cyclopropyl-2-[2-(5,8-dimethyl-[1,2,4]triazol...)
Affinity DataIC50:  27nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM294486(1-{1-Cyclopropyl-2-[2-(5,8-dimethyl-[1,2,4]triazol...)
Affinity DataIC50:  27nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent