BDBM294487 2′-[(E)-2-(5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-vinyl]-3, 1′-dimethyl-4,5-dihydro-3H, 1′H-[1,4′]biimidazolyl-2-one::Roche-Dataset for PDE10A, Compound 907::US9586970, 8

SMILES CN1CCN(C1=O)c1cn(C)c(\C=C\c2nc3c(C)ncc(C)n3n2)n1

InChI Key InChIKey=FDCNTCASGRTLND-AATRIKPKSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 294487   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM294487(2′-[(E)-2-(5,8-Dimethyl-[1,2,4]triazolo[1,5-...)
Affinity DataIC50:  162nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM294487(2′-[(E)-2-(5,8-Dimethyl-[1,2,4]triazolo[1,5-...)
Affinity DataIC50:  162nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent