BDBM294489 1-{2-[(E)-2-{4,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl}ethenyl]-1-methyl-1H-imidazol-4-yl}pyrrolidin-2-one::US9586970, 10

SMILES Cc1cnc(C)c2nc(\C=C\c3nc(cn3C)N3CCCC3=O)nn12

InChI Key InChIKey=KLLQOHYGEXPJOP-VOTSOKGWSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 294489   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM294489(1-{2-[(E)-2-{4,7-dimethyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50:  54.6nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent