BDBM29679 (E)-2-cyano-3-(5-methyl-2-furanyl)-N-(5-quinolinyl)-2-propenamide;hydrochloride::(E)-2-cyano-3-(5-methyl-2-furyl)-N-(5-quinolyl)acrylamide;hydrochloride::(E)-2-cyano-3-(5-methylfuran-2-yl)-N-quinolin-5-yl-prop-2-enamide;hydrochloride::(E)-2-cyano-3-(5-methylfuran-2-yl)-N-quinolin-5-ylprop-2-enamide;hydrochloride::MLS000402164::SMR000263836::cid_15944735

SMILES Cc1ccc(\C=C(/C#N)C(=O)Nc2cccc3ncccc23)o1

InChI Key InChIKey=LLLUNVSIIMWQOM-JLHYYAGUSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 29679   

TargetRunt-related transcription factor 1(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM29679((E)-2-cyano-3-(5-methyl-2-furanyl)-N-(5-quinolinyl...)
Affinity DataIC50:  1.74E+4nMpH: 7.4 T: 2°CAssay Description:This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetRunt-related transcription factor 1(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM29679((E)-2-cyano-3-(5-methyl-2-furanyl)-N-(5-quinolinyl...)
Affinity DataIC50:  1.74E+4nMpH: 7.4 T: 2°CAssay Description:This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetRunt-related transcription factor 1(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM29679((E)-2-cyano-3-(5-methyl-2-furanyl)-N-(5-quinolinyl...)
Affinity DataIC50:  2.50E+4nMpH: 7.4 T: 2°CAssay Description:This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetImportin subunit alpha-1(Homo sapiens (Human))
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM29679((E)-2-cyano-3-(5-methyl-2-furanyl)-N-(5-quinolinyl...)
Affinity DataEC50:  9.41E+4nMAssay Description:Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM29679((E)-2-cyano-3-(5-methyl-2-furanyl)-N-(5-quinolinyl...)
Affinity DataIC50: >1.09E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetBcl-2-like protein 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM29679((E)-2-cyano-3-(5-methyl-2-furanyl)-N-(5-quinolinyl...)
Affinity DataIC50:  1.09E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetRunt-related transcription factor 1(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM29679((E)-2-cyano-3-(5-methyl-2-furanyl)-N-(5-quinolinyl...)
Affinity DataIC50:  2.66E+4nMpH: 7.4 T: 2°CAssay Description:This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay