BDBM297741 1-(3-((cyclopentylamino)methyl)phenoxy)-3-(isoindolin-2-yl)propan-2-ol::US10118918, Compound 20::US9732072, Compound 20
SMILES OC(COc1cccc(CNC2CCCC2)c1)CN1Cc2ccccc2C1
InChI Key InChIKey=XAKRWZAZKPLRIX-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 297741
Affinity DataIC50: 5.50E+3nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme
Curated by ChEMBL
Epizyme
Curated by ChEMBL
Affinity DataIC50: 7.45E+3nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
Affinity DataIC50: 5.50E+3nMAssay Description:General Materials.S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), bicine, KCl, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG)...More data for this Ligand-Target Pair