BDBM297741 1-(3-((cyclopentylamino)methyl)phenoxy)-3-(isoindolin-2-yl)propan-2-ol::US10118918, Compound 20::US9732072, Compound 20

SMILES OC(COc1cccc(CNC2CCCC2)c1)CN1Cc2ccccc2C1

InChI Key InChIKey=XAKRWZAZKPLRIX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 297741   

TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM297741(1-(3-((cyclopentylamino)methyl)phenoxy)-3-(isoindo...)
Affinity DataIC50:  5.50E+3nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM297741(1-(3-((cyclopentylamino)methyl)phenoxy)-3-(isoindo...)
Affinity DataIC50:  7.45E+3nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM297741(1-(3-((cyclopentylamino)methyl)phenoxy)-3-(isoindo...)
Affinity DataIC50:  5.50E+3nMAssay Description:General Materials.S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), bicine, KCl, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent