BDBM298427 4-[[4-[[4-[[5-tert-butyl-3-(methanesulfonamido)-2-methoxy-phenyl]carbamoylamino]-1-naphthyl]oxy]-pyridyl]amino]-2-methoxy-N-[3-(1-oxo-1,4-thiazan-4-yl)propyl]benzamide::US10125100, Example 17(ag)::US10941115, Example 17(ag)::US9751837, Example 17(ag)

SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)ccc1C(=O)NCCCN1CCS(=O)CC1

InChI Key InChIKey=RDUBHIVRDVFUBN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 298427   

TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
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US Patent
LigandPNGBDBM298427(4-[[4-[[4-[[5-tert-butyl-3-(methanesulfonamido)-2-...)
Affinity DataIC50:  17nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
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US Patent
LigandPNGBDBM298427(4-[[4-[[4-[[5-tert-butyl-3-(methanesulfonamido)-2-...)
Affinity DataIC50:  2.75E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
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US Patent
LigandPNGBDBM298427(4-[[4-[[4-[[5-tert-butyl-3-(methanesulfonamido)-2-...)
Affinity DataIC50:  105nMAssay Description:Method 1The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent