BDBM29868 alkynyl ether, 10

SMILES Cc1c(C)c(Sc2ccc(COc3ccc(cc3)C(F)(F)F)cc2OCC#C)ccc1OCC(O)=O

InChI Key InChIKey=RMMWVBYHCKSFMW-UHFFFAOYSA-N

Data  3 KI  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 29868   

TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Amgen

LigandPNGBDBM29868(alkynyl ether, 10)
Affinity DataKi:  4nM EC50:  54nMAssay Description:The human PPARdelta ligand binding was directly measured using a scintillation proximity assay. Plates were read on a Packard TopCount. IC50 values f...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Amgen

LigandPNGBDBM29868(alkynyl ether, 10)
Affinity DataKi:  210nM ΔG°:  -9.01kcal/mole EC50:  6.10E+3nMpH: 7.1 T: 2°CAssay Description:The human PPARalpha ligand binding was directly measured using a scintillation proximity assay. Plates were read on a Packard TopCount. IC50 values f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Amgen

LigandPNGBDBM29868(alkynyl ether, 10)
Affinity DataKi:  300nM EC50:  3.00E+3nMAssay Description:The human PPARgamma ligand binding was directly measured using a filtration assay in a UniFilter 350 96-well assay plate (Polyfiltronics). The reacti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed