BDBM299397 1-acetyl-N-[3- (4-amino- quinazolin- 6-yl)-5-fluoro- phenyl] azetidine-3- carboxamide::US9592235, Example 190::US9855269, Compound 36

SMILES CC(=O)N1CC(C1)C(=O)Nc1cc(F)cc(c1)-c1ccc2ncnc(N)c2c1

InChI Key InChIKey=VVYCZBIUAJKJMS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 299397   

TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM299397(1-acetyl-N-[3- (4-amino- quinazolin- 6-yl)-5-fluor...)
Affinity DataIC50:  172nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM299397(1-acetyl-N-[3- (4-amino- quinazolin- 6-yl)-5-fluor...)
Affinity DataIC50:  172nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent