BDBM299436 N6-[2-(4-fluoro- phenyl)ethyl] pyrido[3,2-d] pyrimidine- 4,6-diamine::US9592235, Example 225::US9855269, Compound 72

SMILES Nc1ncnc2ccc(NCCc3ccc(F)cc3)nc12

InChI Key InChIKey=MAUQWFRCYUDOSP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 299436   

TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM299436(N6-[2-(4-fluoro- phenyl)ethyl] pyrido[3,2-d] pyrim...)
Affinity DataIC50:  70.1nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM299436(N6-[2-(4-fluoro- phenyl)ethyl] pyrido[3,2-d] pyrim...)
Affinity DataIC50:  70.1nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent