BDBM299490 N-[3-(4-amino- pyrido[3,2-d] pyrimidin-6-yl)- 5-fluoro-phenyl]- 2-cyclopentyl- acetamide::US9592235, Example 263::US9855269, Compound 110

SMILES Nc1ncnc2ccc(nc12)-c1cc(F)cc(NC(=O)CC2CCCC2)c1

InChI Key InChIKey=NWOSZYGCZLWAOJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 299490   

TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM299490(N-[3-(4-amino- pyrido[3,2-d] pyrimidin-6-yl)- 5-fl...)
Affinity DataIC50:  107nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM299490(N-[3-(4-amino- pyrido[3,2-d] pyrimidin-6-yl)- 5-fl...)
Affinity DataIC50:  107nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent