BDBM299617 6-[3-(difluoro- methoxy)phenyl] pyrido[3,2-d] pyrimidin-4-amine::US9592235, Example 363::US9855269, Compound 290

SMILES Nc1ncnc2ccc(nc12)-c1cccc(OC(F)F)c1

InChI Key InChIKey=MGXSZEBSENIQSJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 299617   

TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM299617(6-[3-(difluoro- methoxy)phenyl] pyrido[3,2-d] pyri...)
Affinity DataIC50:  71.8nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM299617(6-[3-(difluoro- methoxy)phenyl] pyrido[3,2-d] pyri...)
Affinity DataIC50:  71.8nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent