BDBM301431 4-amino-7-{1-[1-(2-fluorophenyl)-1H-pyrazol-4-yl]propyl}-5-[2-(trifluoromethyl)pyrimidin-5-yl]pyrrolo[2,1-f][1,2,4]triazine-6-carbonitrile,enantiomer 1::BDBM301432::US10131670, Example 14
SMILES CCC(c1cnn(c1)-c1ccccc1F)c1c(C#N)c(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12
InChI Key InChIKey=HAHMBFBJDYSEEL-UHFFFAOYSA-N
Data 4 EC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 301431
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Cystic Fibrosis Foundation Therapeutics
US Patent
Cystic Fibrosis Foundation Therapeutics
US Patent
Affinity DataEC50: 2nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Cystic Fibrosis Foundation Therapeutics
US Patent
Cystic Fibrosis Foundation Therapeutics
US Patent
Affinity DataEC50: 0.560nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Cystic Fibrosis Foundation Therapeutics
US Patent
Cystic Fibrosis Foundation Therapeutics
US Patent
Affinity DataEC50: 0.200nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Cystic Fibrosis Foundation Therapeutics
US Patent
Cystic Fibrosis Foundation Therapeutics
US Patent
Affinity DataEC50: 6.59nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair