BDBM304149 (R)-4-[(3-bicyclo[1.1.1]pent-1-yl-2-{5-[3-chloro-6-(difluoromethoxy)-2-fluorophenyl]-1-oxidopyridin-2-yl}propanoyl)amino]benzoic Acid::US10143681, Example 52

SMILES OC(=O)c1ccc(NC(=O)[C@H](CC23CC(C2)C3)c2ccc(c[n+]2[O-])-c2c(F)c(Cl)ccc2OC(F)F)cc1

InChI Key InChIKey=MYUCKYTVMPEQIE-FXVQNQHISA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 304149   

TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304149((R)-4-[(3-bicyclo[1.1.1]pent-1-yl-2-{5-[3-chloro-6...)
Affinity DataIC50:  14nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304149((R)-4-[(3-bicyclo[1.1.1]pent-1-yl-2-{5-[3-chloro-6...)
Affinity DataIC50:  0.930nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent