BDBM304207 2-(1-((4- carboxyphenyl)amino)-3- (2,3-dimethylcyclopropyl)- 1-oxopropan-2-yl)-5-(3- chloro-6-(difluoromethoxy)- 2-fluorophenyl)pyridine 1- oxide::US10143681, Example 100::US10143681, Example 98::US10143681, Example 99

SMILES CC1C(C)C1CC(C(=O)Nc1ccc(cc1)C(O)=O)c1ccc(c[n+]1[O-])-c1c(F)c(Cl)ccc1OC(F)F

InChI Key InChIKey=GUCHYZAIJAAHRC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 304207   

TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304207(2-(1-((4- carboxyphenyl)amino)-3- (2,3-dimethylcyc...)
Affinity DataIC50:  0.300nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304207(2-(1-((4- carboxyphenyl)amino)-3- (2,3-dimethylcyc...)
Affinity DataIC50:  11.3nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304207(2-(1-((4- carboxyphenyl)amino)-3- (2,3-dimethylcyc...)
Affinity DataIC50:  144nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304207(2-(1-((4- carboxyphenyl)amino)-3- (2,3-dimethylcyc...)
Affinity DataIC50:  92nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304207(2-(1-((4- carboxyphenyl)amino)-3- (2,3-dimethylcyc...)
Affinity DataIC50:  2.10nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent