BDBM30491 1,1-dioxoisothiazole analog., 35

SMILES CN(Cc1cccc2C(NS(=O)(=O)c12)=C1C(=O)[C@@H](N(Cc2ccc(F)c(Cl)c2)C1=O)C(C)(C)C)S(C)(=O)=O

InChI Key InChIKey=NMUYLJJGRSUIAI-HSZRJFAPSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 30491   

TargetGenome polyprotein(Hepatitis C virus (HCV))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM30491(1,1-dioxoisothiazole analog., 35)
Affinity DataIC50:  10nMAssay Description:Inhibition of HSV1b con1 NS5B polymerase assessed as [3H]UTP incorporation into acid insoluble RNA productMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30491(1,1-dioxoisothiazole analog., 35)
Affinity DataIC50:  23nM EC50:  90nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed