BDBM307529 (S)-3-((3-(4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxyphenoxy)propyl)(ethyl)amino)propanoic acid::BDBM307530::US10150743, Example 10::US10562861, Ex. No. 11

SMILES CCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1ccc(OCCCN(CC)CC(O)=O)cc1OC

InChI Key InChIKey=QZFXSCDMRRGGHK-FQEVSTJZSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 307529   

TargetToll-like receptor 7(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM307529((S)-3-((3-(4-((2-amino-4-(1-hydroxyhexan-3-ylamino...)
Affinity DataEC50:  6.60E+3nMAssay Description:Recombinant human TLR7 was stably expressed in a HEK293 cell line already stably expressing the pNiFty2-SEAP reporter plasmid; integration of the rep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM307529((S)-3-((3-(4-((2-amino-4-(1-hydroxyhexan-3-ylamino...)
Affinity DataEC50:  6.70E+3nMAssay Description:Recombinant human TLR7 was stably expressed in a HEK293 cell line already stably expressing the pNiFty2-SEAP reporter plasmid; integration of the rep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 8(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM307529((S)-3-((3-(4-((2-amino-4-(1-hydroxyhexan-3-ylamino...)
Affinity DataEC50: >1.00E+4nMAssay Description:TLR8/NF-kB/SEAPorter™ HEK 293 Cell Line (Imgenex Corporation) is a stably co-transfected cell line which expresses full-length human TLR8 and the sec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 8(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM307529((S)-3-((3-(4-((2-amino-4-(1-hydroxyhexan-3-ylamino...)
Affinity DataEC50: <1.00E+4nMAssay Description:TLR8/NF-kB/SEAPorter HEK 293 Cell Line (Imgenex Corporation) is a stably co-transfected cell line which expresses full-length human TLR8 and the secr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM307529((S)-3-((3-(4-((2-amino-4-(1-hydroxyhexan-3-ylamino...)
Affinity DataEC50:  200nMAssay Description:Recombinant human TLR7 was stably expressed in a HEK293 cell line already stably expressing the pNiFty2-SEAP reporter plasmid; integration of the rep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 8(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM307529((S)-3-((3-(4-((2-amino-4-(1-hydroxyhexan-3-ylamino...)
Affinity DataEC50: <1.00E+4nMAssay Description:TLR8/NF-kB/SEAPorter HEK 293 Cell Line (Imgenex Corporation) is a stably co-transfected cell line which expresses full-length human TLR8 and the secr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent