BDBM310198 4-bromo-6-hydroxy-2-(4-hydroxyphenyl)isoquinolin-1(2H)-one::US9604931, 12b::US9623021, Compound 12b

SMILES Oc1ccc(cc1)-n1cc(Br)c2cc(O)ccc2c1=O

InChI Key InChIKey=BIUDJVBDYHJCCR-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 310198   

TargetSteroid hormone receptor ERR2(Homo sapiens (Human))
Gtx

US Patent
LigandPNGBDBM310198(4-bromo-6-hydroxy-2-(4-hydroxyphenyl)isoquinolin-1...)
Affinity DataKi:  49nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor beta(Homo sapiens (Human))
Gtx

US Patent
LigandPNGBDBM310198(4-bromo-6-hydroxy-2-(4-hydroxyphenyl)isoquinolin-1...)
Affinity DataKi:  49nMAssay Description:Recombinant ER-α or ER-β ligand binding domain (LBD) was combined with [3H]E2 (PerkinElmer, Waltham, Mass.) in buffer A (10 mM Tris, pH 7.4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Gtx

US Patent
LigandPNGBDBM310198(4-bromo-6-hydroxy-2-(4-hydroxyphenyl)isoquinolin-1...)
Affinity DataKi:  998nMAssay Description:Recombinant ER-α or ER-β ligand binding domain (LBD) was combined with [3H]E2 (PerkinElmer, Waltham, Mass.) in buffer A (10 mM Tris, pH 7.4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSteroid hormone receptor ERR1(Homo sapiens (Human))
Gtx

US Patent
LigandPNGBDBM310198(4-bromo-6-hydroxy-2-(4-hydroxyphenyl)isoquinolin-1...)
Affinity DataKi:  998nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent