BDBM310631 US10150762, Example 2/16

SMILES C[C@@H]1CCCN1C(=O)c1nc(sc1-c1ccc(c(Cl)c1Cl)C(O)(C(F)(F)F)C(F)(F)F)C(=O)NCC(C)(C)O

InChI Key InChIKey=ZQHVEGQHOKDZEN-SNVBAGLBSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 310631   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM310631(US10150762, Example 2/16)
Affinity DataIC50:  430nMAssay Description:Cells used in this assay were transiently co-transfected with three different plasmids, one expressing the GAL4-DNA binding domain (DBD)-RORγt f...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNuclear receptor ROR-beta(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM310631(US10150762, Example 2/16)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of GAL4 DNA-binding domain fused full length human RORbeta (201 to 459 residues) expressed in HEK293T cells incubated for 16 to 20 hrs by ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNuclear receptor ROR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM310631(US10150762, Example 2/16)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of GAL4 DNA-binding domain fused full length human RORalpha (305 to 556 residues) expressed in HEK293T cells incubated for 16 to 20 hrs by...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM310631(US10150762, Example 2/16)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of GAL4 DNA-binding domain fused full length human RORgammat (1 to 497 residues) expressed in HEK293T cells incubated for 16 to 20 hrs by ...More data for this Ligand-Target Pair
In DepthDetails PubMed