BDBM310927 N-cyclopropyl-2,2-difluoro-2-(4-(thiophen-3-yl)-3-(3-(3-(trifluoromethyl)phenyl) ureido)phenyl)acetamide::US10155722, Example 1

SMILES FC(F)(F)c1cccc(NC(=O)Nc2cc(ccc2-c2ccsc2)C(F)(F)C(=O)NC2CC2)c1

InChI Key InChIKey=KWXASARDXHORBK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 310927   

TargetIsocitrate dehydrogenase [NADP], mitochondrial(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM310927(N-cyclopropyl-2,2-difluoro-2-(4-(thiophen-3-yl)-3-...)
Affinity DataIC50:  14.2nMAssay Description:The inhibitory activity of a compound against IDH2 (R172K, 40-end) was determined by the decrease of a helper factor NADPH. The test compound was pre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent