BDBM311261 (S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-(difluoromethyl)-[2,4′-bipyridin]-2′-yl)carbamate::US10155760, Example 117::US10351563, Example 117::US10544120, Example 117::US10723734, Example 117::US10981910, Example 117::US9902722, Example 117

SMILES COC(=O)Nc1cc(ccn1)-c1ccc(OC[C@@](C)(N)CC(C)C)c(n1)C(F)F

InChI Key InChIKey=SVNVPNHWFJFRLZ-FQEVSTJZSA-N

Data  1 KI  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 311261   

TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311261((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataKi:  0.0700nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311261((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of TYRO3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311261((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  1nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311261((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  1nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311261((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  1nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 Cl prepared from 15 μl additions of enzyme and substrates (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311261((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  1nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311261((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of bacterially expressed GST-Xa-tagged human AAK1 using 5-FAM-labelled Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incubated for 3 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311261((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBMP-2-inducible protein kinase(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311261((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of BIKE (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDeath-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311261((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  560nMAssay Description:Inhibition of DAPK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311261((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  160nMAssay Description:Inhibition of GAK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311261((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  120nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDeath-associated protein kinase 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311261((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of DAPK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHomeodomain-interacting protein kinase 4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311261((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  650nMAssay Description:Inhibition of HIPK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311261((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  370nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMyotonin-protein kinase(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311261((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of DMPK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311261((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  140nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311261((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  1nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311261((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  1nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent