BDBM312073 3-(6-bromo-5-fluoro- 1H-indol-3-yl)- pyrrolidine-2,5-dione::US9603836, Compound 9::US9949951, 9

SMILES Fc1cc2c(c[nH]c2cc1Br)C1CC(=O)NC1=O

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 312073   

TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM312073(3-(6-bromo-5-fluoro- 1H-indol-3-yl)- pyrrolidine-2...)
Affinity DataIC50:  290nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM312073(3-(6-bromo-5-fluoro- 1H-indol-3-yl)- pyrrolidine-2...)
Affinity DataIC50:  290nMAssay Description:Inhibition of human recombinant IDO-1 using L-Trp as substrate after 15 mins by PDMAB-based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM312073(3-(6-bromo-5-fluoro- 1H-indol-3-yl)- pyrrolidine-2...)
Affinity DataIC50:  290nMAssay Description:The compounds of the present invention inhibit the enzymatic activity of human IDO1.To measure enzymatic activity of human IDO1, the reaction mixture...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent