BDBM312188 6-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)-2H-benzo[b][1,4]oxazin-3(4H)-one::US10441590, Compound B::US9604944, 15b (Example 14)::US9975862, 15b (Example 14)

SMILES Clc1cccc(N2CCN(CCCCOc3ccc4OCC(=O)Nc4c3)CC2)c1Cl

InChI Key InChIKey=PMKMNTBZJOXTJW-UHFFFAOYSA-N

Data  12 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 312188   

Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Reviva Pharmaceuticals

US Patent
LigandPNGBDBM312188(6-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)...)
Affinity DataKi:  0.190nMAssay Description:Serotonin, 5HT1A: Materials and Methods:Receptor Source: Human recombinant 5-HT1A expressed mammalian cellsRadioligand: [3H]-8-OH-DPAT (221 Ci/mmol)C...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Reviva Pharmaceuticals

US Patent
LigandPNGBDBM312188(6-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)...)
Affinity DataKi:  0.610nM IC50:  1.96nMAssay Description:Receptor Source: Human recombinant expressed in CHO cells Radioligand: [3H]Spiperone (20-60 Ci/mmol) Control Compound: Haloperidol Incubatio...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Reviva Pharmaceuticals

US Patent
LigandPNGBDBM312188(6-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)...)
Affinity DataKi:  0.610nMAssay Description:Dopamine, D2S: Materials and Methods: Receptor Source: Human recombinant expressed in CHO cells Radioligand: [3H]Spiperone (20-60 Ci/mmol) C...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Reviva Pharmaceuticals

US Patent
LigandPNGBDBM312188(6-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)...)
Affinity DataKi:  0.620nMAssay Description:Dopamine, D2s: Radioligand: [3H]Spiperone (20-60 Ci/mmol) or [3H]-7-hydroxy DPAT, 1.0 nMControl Compound: Haloperidol or ChlorpromazineIncubation Con...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Reviva Pharmaceuticals

US Patent
LigandPNGBDBM312188(6-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)...)
Affinity DataKi:  1.5nM IC50:  2.25nMAssay Description:Receptor Source: Human recombinant expressed in HEK-293 cells Radioligand: [3H]-8-OH-DPAT (221 Ci/mmol) Control Compound: 8-OH-DPAT Incubati...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Reviva Pharmaceuticals

US Patent
LigandPNGBDBM312188(6-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)...)
Affinity DataKi:  1.5nMAssay Description:Serotonin, 5HT1A:Receptor Source: Human recombinant expressed in HEK-293 cellsRadioligand: [3H]-8-OH-DPAT (221 Ci/mmol)Control Compound: 8-OH-DPATInc...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Reviva Pharmaceuticals

US Patent
LigandPNGBDBM312188(6-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)...)
Affinity DataKi:  1.5nMAssay Description:Serotonin, 5HT1A: Materials and Methods:Receptor Source: Human recombinant 5-HT1A expressed mammalian cellsRadioligand: [3H]-8-OH-DPAT (221 Ci/mmol)C...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Reviva Pharmaceuticals

US Patent
LigandPNGBDBM312188(6-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)...)
Affinity DataKi:  2.5nMAssay Description:Serotonin, 5HT1A: Materials and Methods:Receptor Source: Human recombinant 5-HT1A expressed mammalian cellsRadioligand: [3H]-8-OH-DPAT (221 Ci/mmol)C...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Reviva Pharmaceuticals

US Patent
LigandPNGBDBM312188(6-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)...)
Affinity DataKi:  2.70nMAssay Description:Serotonin, 5HT1A: Materials and Methods:Receptor Source: Human recombinant 5-HT1A expressed mammalian cellsRadioligand: [3H]-8-OH-DPAT (221 Ci/mmol)C...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Reviva Pharmaceuticals

US Patent
LigandPNGBDBM312188(6-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)...)
Affinity DataKi:  51nMAssay Description:Serotonin, 5HT1A: Materials and Methods:Receptor Source: Human recombinant 5-HT1A expressed mammalian cellsRadioligand: [3H]-8-OH-DPAT (221 Ci/mmol)C...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Reviva Pharmaceuticals

US Patent
LigandPNGBDBM312188(6-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)...)
Affinity DataKi:  58.5nM IC50:  130nMAssay Description:Receptor Source: Human Cortex Radioligand: [3H]-Ketanserin (60-90 Ci/mmol) Control Compound: Ketanserin Incubation Conditions: The reactions...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Reviva Pharmaceuticals

US Patent
LigandPNGBDBM312188(6-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)...)
Affinity DataKi:  58.5nMAssay Description:Serotonin, 5HT2A :Materials and Methods: Receptor Source: Human Cortex Radioligand: [3H]-Ketanserin (60-90 Ci/mmol) Control Compound: Ketans...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Reviva Pharmaceuticals

US Patent
LigandPNGBDBM312188(6-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)...)
Affinity DataIC50:  130nMAssay Description:Serotonin, 5HT2A :Materials and Methods: Receptor Source: Human Cortex Radioligand: [3H]-Ketanserin (60-90 Ci/mmol) Control Compound: Ketans...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Reviva Pharmaceuticals

US Patent
LigandPNGBDBM312188(6-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)...)
Affinity DataIC50:  2.25nMAssay Description:Serotonin, 5HT1A:Receptor Source: Human recombinant expressed in HEK-293 cellsRadioligand: [3H]-8-OH-DPAT (221 Ci/mmol)Control Compound: 8-OH-DPATInc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Reviva Pharmaceuticals

US Patent
LigandPNGBDBM312188(6-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)...)
Affinity DataIC50:  1.96nMAssay Description:Dopamine, D2S: Materials and Methods: Receptor Source: Human recombinant expressed in CHO cells Radioligand: [3H]Spiperone (20-60 Ci/mmol) C...More data for this Ligand-Target Pair
In DepthDetails US Patent