BDBM31314 1,4-benzodiazepine-2,5-dione, 12k

SMILES C[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)N(CCCN2CCN(C)CC2)c2ccc(I)cc2C1=O)c1ccc(Cl)cc1N

InChI Key InChIKey=NUKCQDDVORQLDB-OLILMLBXSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 31314   

TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM31314(1,4-benzodiazepine-2,5-dione, 12k)
Affinity DataIC50:  704nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM31314(1,4-benzodiazepine-2,5-dione, 12k)
Affinity DataIC50:  546nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed