BDBM315277 6-(4-Methyl-piperazin-1- yl)-1-{1-[5-methyl-2-(4- trifluoromethyl-phenyl)- 1H-imidazol-4- ylmethyl]-piperidin-4- yl}-1,3-dihydro- benzoimidazol-2-one::US10172843, Example 11

SMILES CN1CCN(CC1)c1ccc2[nH]c(=O)n(C3CCN(Cc4nc([nH]c4C)-c4ccc(cc4)C(F)(F)F)CC3)c2c1

InChI Key InChIKey=XVULNBXARQKBLC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 315277   

TargetCathepsin S(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM315277(6-(4-Methyl-piperazin-1- yl)-1-{1-[5-methyl-2-(4- ...)
Affinity DataIC50:  460nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent