BDBM315649 US10172859, Example 74::US11065253, Example 256::US9732094, Example 74::[4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)phenyl]- (6-methoxypyridazin-3- yl)methanol1H NMR (400 MHz, DMSO-d6) ppm = 9.09 (s, 1H), 7.69 (d, J = 9.2, 1H), 7.67-7.61 (m, 2H), 7.54- 7.48 (m, 2H), 7.42-7.36 (m, 1H), 7.22-7.17 (m, 2H), 6.51-6.45 (m, 1H), 6.04-6.00 (m, 1H), 4.00 (s, 3H), 3.80-3.74 (m, 4H), 3.47-3.41 (m, 4H)

SMILES COc1ccc(nn1)C(O)c1ccc(F)c(c1)-c1ncnc2cc(ccc12)N1CCOCC1

InChI Key InChIKey=IDTQOMSFKJPUNB-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 315649   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315649(US10172859, Example 74 | US11065253, Example 256 |...)
Affinity DataKi: >2.50E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315649(US10172859, Example 74 | US11065253, Example 256 |...)
Affinity DataKi: >2.50E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315649(US10172859, Example 74 | US11065253, Example 256 |...)
Affinity DataIC50: <3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315649(US10172859, Example 74 | US11065253, Example 256 |...)
Affinity DataIC50: <3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315649(US10172859, Example 74 | US11065253, Example 256 |...)
Affinity DataIC50: <3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315649(US10172859, Example 74 | US11065253, Example 256 |...)
Affinity DataIC50: <3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent