BDBM317010 N-[2,4-Difluoro-3-(4- pyrrolidin-1-yl-7H- pyrrolo[2,3-d]pyrimidine-5- carbonyl)-phenyl]-4- trifluoromethyl- benzenesulfonamide::US9617267, Compound P-1061

SMILES Fc1ccc(NS(=O)(=O)c2ccc(cc2)C(F)(F)F)c(F)c1C(=O)c1c[nH]c2ncnc(N3CCCC3)c12

InChI Key InChIKey=GXKKUVBNTUKHAV-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 317010   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317010(N-[2,4-Difluoro-3-(4- pyrrolidin-1-yl-7H- pyrrolo[...)
Affinity DataIC50: >100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317010(N-[2,4-Difluoro-3-(4- pyrrolidin-1-yl-7H- pyrrolo[...)
Affinity DataIC50: >100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317010(N-[2,4-Difluoro-3-(4- pyrrolidin-1-yl-7H- pyrrolo[...)
Affinity DataIC50: >100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 1A2(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317010(N-[2,4-Difluoro-3-(4- pyrrolidin-1-yl-7H- pyrrolo[...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317010(N-[2,4-Difluoro-3-(4- pyrrolidin-1-yl-7H- pyrrolo[...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317010(N-[2,4-Difluoro-3-(4- pyrrolidin-1-yl-7H- pyrrolo[...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317010(N-[2,4-Difluoro-3-(4- pyrrolidin-1-yl-7H- pyrrolo[...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317010(N-[2,4-Difluoro-3-(4- pyrrolidin-1-yl-7H- pyrrolo[...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C19(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317010(N-[2,4-Difluoro-3-(4- pyrrolidin-1-yl-7H- pyrrolo[...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent