BDBM317628 3-(4-{5- Amino-4-[4- (3-methoxy- benzyl)-1H- indole-2- carbonyl]- pyrazol-1-yl}- 3-methyl- phenoxy)- benzonitrile::US10640491, Compound 17::US11104668, Compound 17::US9624201, Compound 17

SMILES COc1cccc(Cc2cccc3[nH]c(cc23)C(=O)c2cnn(c2N)-c2ccc(Oc3cccc(c3)C#N)cc2C)c1

InChI Key InChIKey=JBYUIVOVDQQFNM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 317628   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM317628(3-(4-{5- Amino-4-[4- (3-methoxy- benzyl)-1H- indol...)
Affinity DataIC50:  21.1nMAssay Description:The assay is a capture of radioactive 33P phosphorylated product through filtration. The interactions of Btk, biotinylated SH2 peptide substrate (Src...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM317628(3-(4-{5- Amino-4-[4- (3-methoxy- benzyl)-1H- indol...)
Affinity DataIC50:  21.1nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM317628(3-(4-{5- Amino-4-[4- (3-methoxy- benzyl)-1H- indol...)
Affinity DataIC50:  21.1nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Flouresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent