BDBM317630 3-{4-[5- Amino-4-(4- cyanomethyl- 1H-indole-2- carbonyl)- pyrazol-1-yl]- 3-methyl- phenoxy}- benzonitrile::US10640491, Compound 20::US11104668, Compound 20::US9624201, Compound 20

SMILES Cc1cc(Oc2cccc(c2)C#N)ccc1-n1ncc(C(=O)c2cc3c(CC#N)cccc3[nH]2)c1N

InChI Key InChIKey=IWPIYCRNKUKHCZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 317630   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM317630(3-{4-[5- Amino-4-(4- cyanomethyl- 1H-indole-2- car...)
Affinity DataIC50:  8.45nMAssay Description:The assay is a capture of radioactive 33P phosphorylated product through filtration. The interactions of Btk, biotinylated SH2 peptide substrate (Src...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM317630(3-{4-[5- Amino-4-(4- cyanomethyl- 1H-indole-2- car...)
Affinity DataIC50:  8.45nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM317630(3-{4-[5- Amino-4-(4- cyanomethyl- 1H-indole-2- car...)
Affinity DataIC50:  8.45nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Flouresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent