BDBM31810 Apogossypol derivative, 8r

SMILES CC(CNC(=O)c1c(O)c(O)cc2c(O)c(c(C)cc12)-c1c(C)cc2c(C(=O)NCC(C)c3ccccc3)c(O)c(O)cc2c1O)c1ccccc1

InChI Key InChIKey=RAYNZUHYMMLQQA-UHFFFAOYSA-N

Data  12 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 31810   

TargetBcl-2-like protein 1(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  760nM Kd:  110nMpH: 7.4 T: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  320nMpH: 7.4 T: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  280nMpH: 7.4 T: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-related protein A1(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  730nMT: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  330nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  200nMAssay Description:Inhibition of Mcl-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  660nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bcl-2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  390nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bcl-XL after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-related protein A1(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  620nMAssay Description:Inhibition of Bfl-1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  310nMAssay Description:Inhibition of Bcl-xl (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  320nMAssay Description:Inhibition of Bcl-2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBcl-2-related protein A1(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50:  420nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bfl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed