BDBM319543 N-[(cyclopropyl- carbamoyl) methyl]-2- methanesulfonyl- 2-(6-phenyl-1,3- benzothiazol- 2-yl)acetamide::US10173991, Example 608

SMILES CS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2ccc(cc2s1)-c1ccccc1

InChI Key InChIKey=GHCPCACIMXRWEZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 319543   

TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM319543(N-[(cyclopropyl- carbamoyl) methyl]-2- methanesulf...)
Affinity DataIC50:  152nMAssay Description:Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatic triacylglycerol lipase(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM319543(N-[(cyclopropyl- carbamoyl) methyl]-2- methanesulf...)
Affinity DataIC50:  47nMAssay Description:Inhibition of human hepatic lipase expressed in African green monkey COS7 cells using PED-A1 as substrate incubated for 20 mins and measured every 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM319543(N-[(cyclopropyl- carbamoyl) methyl]-2- methanesulf...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human endothelial lipase derived from human HT1080 cell conditioned media using PED-A1 as substrate incubated for 20 mins and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed