BDBM319586 US10174007, Example 5::US10787438, Example 5::US10988463, Example 5::US11634410, Example 5
SMILES C[C@H]1[C@H](O)CN1c1nc(cc(n1)C(F)(F)F)N1C[C@H]2[C@H](CC(O)=O)[C@H]2C1
InChI Key InChIKey=BCRDBPWNFULPMK-LADJIXMOSA-N
Data 17 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 319586
Affinity DataIC50: 95.5nMAssay Description:Assay D was performed using human KHK-A to assess the potency of compounds in inhibiting activity of this enzyme. Compounds were prepared in DMSO as ...More data for this Ligand-Target Pair
Affinity DataIC50: 24.7nMAssay Description:A 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepared in DM...More data for this Ligand-Target Pair
Affinity DataIC50: 13.6nMAssay Description:Using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were prepared ...More data for this Ligand-Target Pair
Affinity DataIC50: 58.8nMAssay Description:Assay C was performed at high fructose and ATP concentrations, conditions that would be more consistent with physiological concentrations of the natu...More data for this Ligand-Target Pair