BDBM319752 US10174013, Example 1A::US10174013, Example 1X::US10174013, Example 1Y

SMILES CCn1c(nc2c(c(Br)c(Br)cc12)[N+]([O-])=O)N1CCNCC1

InChI Key InChIKey=UNUPAGHCXHMCOJ-UHFFFAOYSA-N

Data  3 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 319752   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Selvita

US Patent
LigandPNGBDBM319752(US10174013, Example 1A | US10174013, Example 1X | ...)
Affinity DataIC50:  1.60E+3nMAssay Description:The hERG (human ether-A-go-go-related gene) channel corresponds to an important anti-target for potential new drugs since its inhibition may lead to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Selvita

US Patent
LigandPNGBDBM319752(US10174013, Example 1A | US10174013, Example 1X | ...)
Affinity DataIC50:  2.04E+4nMAssay Description:The hERG (human ether-A-go-go-related gene) channel corresponds to an important anti-target for potential new drugs since its inhibition may lead to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Selvita

US Patent
LigandPNGBDBM319752(US10174013, Example 1A | US10174013, Example 1X | ...)
Affinity DataIC50:  1.69E+4nMAssay Description:The hERG (human ether-A-go-go-related gene) channel corresponds to an important anti-target for potential new drugs since its inhibition may lead to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3 [D835Y](Homo sapiens (Human))
Selvita

US Patent
LigandPNGBDBM319752(US10174013, Example 1A | US10174013, Example 1X | ...)
Affinity DataKd:  46nMAssay Description:Selected compounds were also tested for their binding properties against FLT3 kinase mutants using suitable in vitro assays (performed according to s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Selvita

US Patent
LigandPNGBDBM319752(US10174013, Example 1A | US10174013, Example 1X | ...)
Affinity DataKd:  74nMAssay Description:Selected compounds were also tested for their binding properties against FLT3 kinase mutants using suitable in vitro assays (performed according to s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3 [D835H](Homo sapiens (Human))
Selvita

US Patent
LigandPNGBDBM319752(US10174013, Example 1A | US10174013, Example 1X | ...)
Affinity DataKd:  120nMAssay Description:Selected compounds were also tested for their binding properties against FLT3 kinase mutants using suitable in vitro assays (performed according to s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Selvita

US Patent
LigandPNGBDBM319752(US10174013, Example 1A | US10174013, Example 1X | ...)
Affinity DataKd:  400nMAssay Description:Selected compounds were also tested for their binding properties against FLT3 kinase mutants using suitable in vitro assays (performed according to s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent