BDBM319787 5,6-dibromo-4-nitro-2-(piperazin-1-yl)-1-(propan-2-yl)-1H-1,3-benzodiazole::US10174013, Example 2A

SMILES CC(C)n1c(nc2c(c(Br)c(Br)cc12)[N+]([O-])=O)N1CCNCC1

InChI Key InChIKey=OXXGIJXWBGSRMV-UHFFFAOYSA-N

Data  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 319787   

TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Selvita

US Patent
LigandPNGBDBM319787(5,6-dibromo-4-nitro-2-(piperazin-1-yl)-1-(propan-2...)
Affinity DataKd:  130nMAssay Description:Selected compounds were also tested for their binding properties against FLT3 kinase mutants using suitable in vitro assays (performed according to s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3 [D835Y](Homo sapiens (Human))
Selvita

US Patent
LigandPNGBDBM319787(5,6-dibromo-4-nitro-2-(piperazin-1-yl)-1-(propan-2...)
Affinity DataKd:  15nMAssay Description:Selected compounds were also tested for their binding properties against FLT3 kinase mutants using suitable in vitro assays (performed according to s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3 [D835H](Homo sapiens (Human))
Selvita

US Patent
LigandPNGBDBM319787(5,6-dibromo-4-nitro-2-(piperazin-1-yl)-1-(propan-2...)
Affinity DataKd:  28nMAssay Description:Selected compounds were also tested for their binding properties against FLT3 kinase mutants using suitable in vitro assays (performed according to s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Selvita

US Patent
LigandPNGBDBM319787(5,6-dibromo-4-nitro-2-(piperazin-1-yl)-1-(propan-2...)
Affinity DataKd:  18nMAssay Description:Selected compounds were also tested for their binding properties against FLT3 kinase mutants using suitable in vitro assays (performed according to s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent