BDBM320091 3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 258::US10202369, Example 258::US10472354, Example 282

SMILES CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1

InChI Key InChIKey=CPQUPRVXRIYFHX-IAGOWNOFSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 320091   

TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320091(3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methy...)
Affinity DataIC50:  4nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 2(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320091(3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methy...)
Affinity DataIC50:  38nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320091(3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methy...)
Affinity DataIC50:  4nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 2(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320091(3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methy...)
Affinity DataIC50:  38nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 2/3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320091(3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methy...)
Affinity DataIC50:  209nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 2/3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320091(3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methy...)
Affinity DataIC50:  38nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320091(3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methy...)
Affinity DataIC50:  4nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 2/3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320091(3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methy...)
Affinity DataIC50:  38nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320091(3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methy...)
Affinity DataIC50:  8nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320091(3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methy...)
Affinity DataIC50:  4nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent